I enjoy playing it with my nephews and my Brother Kelly. Its pretty cool. As long as you can keep your eyes on your part of the screen and concentrate on what your doing instead of what hes doing, you'll do fine, lol. Do it the other way and your just so much food for Zombies.
FYI: The game has an option of splitting the screen on the horizontal or vertical axis, its up to you and how you like it. A very nice touch i might add.